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scilifelab
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SciLifeLab offers funding for national genomics studies

SciLifeLab welcomes applications for Swedish research projects based on next generation DNA sequencing. In total, this third call will provide 30 million SEK in support for sequence analysis of unique and wellcharacterized sample collections to study either the genetic basis of disease or environmental effects on biodiversity. The Swedish Genomes…

molecular-machine
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Molecular machines – Tiny but significant

A thousand times thinner than a strand of hair, but with an impact as big as the microchip. The Nobel Prize in Chemistry 2016 was awarded to three scientists, Jean-Pierre Sauvage, Sir J. Fraser Stoddart and Bernard L. Feringa, for the design and synthesis of molecular machines. Molecular machines have…

stoddart_photo_jenny_öhman
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J. Fraser Stoddart

Winning the Nobel Prize in chemistry generates a flood of phone calls, emails and invitations, which really was not a surprise to Sir. Fraser Stoddart, PhD, one of a trio of chemists who took the 2016 honors. What Stoddart did find most surprising and gratifying was among all the well-wishes…

sauvage_photo_jenny_öhman
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Nobel Interview: Jean-Pierre Sauvage

As a child, Jean-Pierre Sauvage, PhD, moved often, due to his father’s career in the French army. Postings included North Africa and the U.S. Midwest. But despite the disruptions to his personal relationships and schooling, his interests in mathematics and science remained constant. That interest in science narrowed to a…

neurons
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A new avenue for Huntington therapy

A neuroscientist reports on Huntington disease results and a Nobel Prize reaction. Neural transplants offer a new path to possible Huntington disease (HD) treatments. Experiments with an HD mouse model show that transplanting human neuronal cells delays HD symptoms and death in the mice. The results, published in Nature Communications,…

ES-cells_KI
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New tools to study ES cells

Researchers have identified cell surface markers specific for the very earliest stem cells in the human embryo. These cells are thought to possess great potential for replacing damaged tissue but until now have been difficult to distinguish from classical embryonic stem cells. Fredrik Lanner’s research team at Karolinska Institutet and…

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Yoshinori Ohsumi: Recognizing autophagy

The 2016 Nobel Prize in Physiology or Medicine highlights a process that is integral to aging, cancer, and infectious disease, but has not been well known outside of cell biology. On 7 December 2016, Professor Yoshinori Ohsumi from the Tokyo Institute of Technology received the Nobel Prize in Physiology or…

Simon-Cervenka-Göran-Engberg
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Large-scale Schizophrenia project provides new clues

Researchers at Karolinska Institutet collaborating in the large-scale Karolinska Schizophrenia Project are taking an integrative approach to unravel the disease mechanisms of schizophrenia. The drugs currently available for schizophrenia are designed to alleviate the symptoms, but are only partly successful, as only 20 per cent of the patients become symptom-free.…

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Bilateral tinnitus is hereditary

Researchers have been able to demonstrate the hereditary nature of certain forms of tinnitus, and bilateral tinnitus has been shown to depend on genetic factors, particularly in men. The twin study, which is published in the journal Genetics in Medicine , was conducted by researchers at Karolinska Institutet together with…

Wolf-Watz_Magnus_foto_Mattias_Pettersson
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Frozen chemistry controls bacterial infections

Chemists and molecular biologists at Umeå University have shown that two proteins that bind to one another slow down a chemical reaction central to the course of the disease in the bacteria Yersinia pseudotuberculosis. “The discovery paves way for new insights in the regulation of bacterial virulence. The results have…

alk-produktion
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Data from ALK results in significant change to the GINA asthma management strategy

ALK has announced that for the first time, allergy immunotherapy is now recommended as a treatment option in the Global Initiative for Asthma (GINA) report: Global Strategy for Asthma Management and Prevention. This global strategy is a practical resource developed to guide healthcare professionals and policy makers, and represents the latest…

euan-renee-ki
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Schizophrenia linked to mother’s low weight during pregnancy

Children born to mothers who gained too little weight during pregnancy were at increased risk for schizophrenia and other non-affective psychoses later in life, according to new epidemiological research from Karolinska Institutet. The findings, published in the journal  JAMA Psychiatry , confirm the results of several important historical studies that…