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ES-cells_KI
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New tools to study ES cells

Researchers have identified cell surface markers specific for the very earliest stem cells in the human embryo. These cells are thought to possess great potential for replacing damaged tissue but until now have been difficult to distinguish from classical embryonic stem cells. Fredrik Lanner’s research team at Karolinska Institutet and…

Simon-Cervenka-Göran-Engberg
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Large-scale Schizophrenia project provides new clues

Researchers at Karolinska Institutet collaborating in the large-scale Karolinska Schizophrenia Project are taking an integrative approach to unravel the disease mechanisms of schizophrenia. The drugs currently available for schizophrenia are designed to alleviate the symptoms, but are only partly successful, as only 20 per cent of the patients become symptom-free.…

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Bilateral tinnitus is hereditary

Researchers have been able to demonstrate the hereditary nature of certain forms of tinnitus, and bilateral tinnitus has been shown to depend on genetic factors, particularly in men. The twin study, which is published in the journal Genetics in Medicine , was conducted by researchers at Karolinska Institutet together with…

Wolf-Watz_Magnus_foto_Mattias_Pettersson
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Frozen chemistry controls bacterial infections

Chemists and molecular biologists at Umeå University have shown that two proteins that bind to one another slow down a chemical reaction central to the course of the disease in the bacteria Yersinia pseudotuberculosis. “The discovery paves way for new insights in the regulation of bacterial virulence. The results have…

euan-renee-ki
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Schizophrenia linked to mother’s low weight during pregnancy

Children born to mothers who gained too little weight during pregnancy were at increased risk for schizophrenia and other non-affective psychoses later in life, according to new epidemiological research from Karolinska Institutet. The findings, published in the journal  JAMA Psychiatry , confirm the results of several important historical studies that…

affected-nerve-cells
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Hope for new treatment for Huntington’s disease

Researchers working at Karolinska Institutet in Sweden and University of Southern Denmark have managed to produce short synthetic DNA analogues – oligonucleotides – that bind direct to the gene that is mutated in Huntington’s disease and prevent the production of a protein that damages the nerve cells. The discovery, published in the…

jonas-halfvarson
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New findings on severe intestinal diseases

Patients with severe intestinal diseases have major fluctuations in their bacterial flora, as shown in a new study published in Nature Microbiology. Jonas Halfvarson, researcher at the School of Medical Sciences, Örebro University, notes that flora in patients varied from being healthy to an almost complete disappearance of certain good…

NOK
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NOK 110 million for interdisciplinary biotech projects

The Research Council of Norway is awarding funding to six new projects under the new Centre for Digital Life Norway, which will bring the total number of projects associated with the centre to 12. “Digitalisation is transforming research in the life sciences. The link between biotechnology and digitalisation also opens…

anna-martling-ki
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Improved rectal cancer treatment

A new study from Karolinska Institutet shows that short-course preoperative radiotherapy combined with delayed surgery reduces the adverse side-effects of rectal cancer surgery without compromising its efficacy. Preoperative radiotherapy was gradually introduced in the early 1990s, with a consequent improvement in prognosis for people with rectal cancer and reduction in…

T-lymphocytes attack a migrating cancer cell
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A paradigm-shift in cancer?

Immunotherapy is the 2016 Clinical Cancer Advance of the Year and a promising new strategy for treating cancer. But how far have we come? The American Society of Clinical Oncology (ASCO) justified this year’s choice of Clinical Cancer Advance, immunotherapy, by the fact that no recent advance has been more…