Researchers from Uppsala University in Sweden have shown that a therapeutic vaccine aimed at tumor blood vessels suppresses tumor growth and metastasis.
The work focused on lung metastases in a mouse model for metastatic breast cancer. “The vaccination approach we have employed is not prophylactic but therapeutic, meaning that immunity was induced after the onset of tumorigenesis – a scenario that resembles the clinical conditions much more closely than prophylactic immunization studies, said study leader Anna-Karin Olsson, researcher at the Department of Medical Biochemistry and Microbiology at Uppsala University, said in a press release.
The vaccine resulted in an 80 percent reduction in metastasis, an important finding since most cancer deaths are caused by cancer that has spread in the body, according to the university.
Study results were published in the scientific journal Oncotarget.