The 7th International Conference on Drug Discovery and Toxicology is going to be held during July 13-14, 2020 in Helsinki, Finland.
The main theme of the conference is based upon “Strategies Trends and Technologies for Drug Discovery and toxicology”.
DRUG DISCOVERY CONGRESS 2020 Conference is an multidisciplinary 2-day program with the participation of members from all around the world . This program displays an exhibition of a wide range of sessions involving workshops , keynote speeches, young research forums (YRF), e-posters, oral and poster presentations from professionals of pharmaceutical science. It provides the participants to share their expertise on expertise knowledge on pharmacology pharmaceutics, medicinal chemistry, drug discovery, its future advances, next-generation sequencing, drug safety and also about the new advanced strategies involving bioavailability and bioequivalence research.
Sessions and Tracks
Track 1: Drug Discovery and Development
Drug discovery is a method of identifying a new medicine or drug by an individual using different principles of science such as pharmacology, chemistry, and biology. In olden days, the active pharmaceutical ingredient was identified from traditional remedies or unplanned fortunate discoveries such as Penicillin. But now in modern drug discovery, it consists of identifying a lead component and its optimization. Drug development involves a series of steps in bringing out the newly identified drug into the market after it has been identified through a process of drug discovery
Track 2: Pre-Clinical and Clinical Research
At Preclinical trails the scientist conducts the test of their identified new chemical entities (NCE) on animals or at laboratory experiments. This phase consists of all the parameters which have to be there before conducting it on humans. In clinical trials or research, the test is conducted on humans who may be both healthy and diseased. Its center of activity is to increase the knowledge on the disease and its treatment also the medical devices used for better patient compliance (Experiments happening at the laboratory and test tubes but not in animals or humans is are called in vitro experiments. And done on animals and humans is referred as in vivo experiments.)
Track 3: Role of Nanotechnology in Drug Discovery
Nanotechnology is a branch of research and technology worried about things that usually build by materials and devices on a small scale of atoms and molecules. the dramatic devolvement in nanotechnology as an established number of solutions for the scientist and researchers about the analysis technique, quality data, and using less sample volume. These advancements in drug discovery have overcome the initial challenges, unrealistic data, and other issues.
Track 4: Novel Techniques in Chromatography
Chromatography is a method of separation, identification, and purification of one or more mixed compounds in a mixture this separation is based on the relative amounts of solute, mobile phase, and continuous phase. In spite of many analytic techniques, chromatographic methods are more widely used its applications have been intensively grown in the past few years. The main principle of operation when a mixture is applied to the stationary phase it gets separated from each other based on the affinities towards the mobile phase.
Track 5: Bioinformatics and Pharmacogenomics in Drug Discovery
Bioinformatics includes biological studies using computer programming as part of their approach along with a specific analysis of “pipelines” that are continuously used, specifically used in the field of genomics. Bioinformatics commonly used for identification of person genes and single nucleotide polymorphisms (SNPs). Frequently such identification is made for a better understanding of the genetic cause of disease, its adaptations, necessary properties or differences among populations. Bioinformatics also understands the disciplines within nucleic acid and protein sequences, called proteomics. Whereas, Pharmacogenomics also called pharmacogenetics is a part of the research that explains the person’s genes and how it affects and responds to medications. Its main goal is to help doctors choose the medication and doses for individual person.
Track 6: Molecular Modeling In Drug Designing
Molecular modeling is a key method of a simulation framework for designing a rational, novel, and biologically active pharmaceutical component This method can be applied for solving various problems for achieving the desired effect by blocking or enhancing the therapeutic activity at a targeted receptor by using a ligand. Usually, a ligand acts by inhibiting the molecule either by binding to an enzyme active site or a regulatory site or to a gene sequencing at the first case it plays the role of a gene repressor. It also acts as an activator by binding to regulatory sites the main aim goal of it is finding a small molecule for binding in a specific way and also with a high affinity to the given receptor. The importance of specificity is for avoiding adverse or side effects, and high affinity is to ensure the desired therapeutic effects.
Track 7: Quality Assurance and Quality Control
Quality management makes it certain for an organization or product to be consonant. The four main components are Quality planning, Quality control, and Quality Improvement, Quality assurance. This not only focuses on product and service quality but also on the ways of achieving it. Quality assurance (QA) is a process of checking defects to avoiding problems during the manufacturing process. The defect prevention and defect detection are two aspects of quality assurance, Quality management uses quality assurance and control tools along with products to achieve more consonant quality. Product validation is a way of establishing complete evidence of the procedure, process, and activity carried
Track 8: Biomarkers and Proteomics in Drug Discovery
Proteomics is a way of characterizing the protein structure, its function, protein-protein binding, and peptide modifications. It has provided an understanding of the disruption in the signaling pathways inside the tumor cells and also enhanced the discovery of new therapeutic targets along with possible indicators of response with a duration of therapy. By the discovery, verification, and validation of novel biomarkers brought an improved clinical development of targeted compounds, for a uniform and rational treatments for patients whose tumors are dependent upon particular signaling pathways. More studies are undergoing several diseases for examining the type of human proteome. Potential assay verification and biological validation of biomarkers will speed up the development of possible agents for targeting the dominant pathways.
Track 9: Novel Drug Delivery System
Recent advancements in pharmacokinetic & pharmacodynamic behavior of drugs have offered a better approach for the development of optimal drug delivery systems. And this led to the devolvement of novel drug delivery systems. It is a process of delivering a drug or medicine to a patient for a specific part by increasing its concentration of dose to achieve its therapeutic effect. This can be easily delivered by using Nanomedicine, made of nanoparticles. This nanoparticle-mediated drug delivery system as overcoming the convectional system of drug delivery the nanoparticles will be loaded with drug and other excipients and target to specific parts of the body. The nasal and pulmonary routes of administration are gaining immense importance by providing an alternative to the parental drug delivery system.
Track 10: Toxicology
Toxicology is a branch of science that deals with chemicals and toxins which causes harm to human life and other living things. Measuring the amount of drug toxicity in a substance is a major thing to be achieved. Chemicals become only toxic when they are changed into different chemical forms by the body. A large number of chemicals become toxic in the liver by enzymes, for instance, paracetamol, a common drug used for pyrexia. this is caused due to changes in liver enzymes by genes in different people causing a substance to be more toxic in one person than it is in another. Toxicology on the whole deals with the adverse effects caused due to the number of reasons such as increased dose, alteration of dosage, dosage regimen, and other patient-related factors. Toxicology has a good scope in the near future.
Track 11: Public Health Toxicology
The rapid increase of synthetic organic chemicals has had brought much risk to human health and the environment. In addition, numerous number of these environment hazards are present in the environment, they get pile up in human tissue, and are not sufficient for testing the ecological and human health effects. The routes of human subjection to chemicals in the environment are multiple. Chemicals present in the air, food, water, and soil could be inhaled, ingested, or absorbed in numerous ways Such exposures occur at home, work, and school, besides through vehicles, at public buildings, and outdoor environments. Dangered inhabitants, such as children, the elder citizen, the unhealthy and the poor are at increased risk of harm relative to environmental contamination due to biologic and demographic factors, including where they stay. Due to improved changes in the health sector, many persons gained knowledge about the importance of health care.
Track 12: Risk Assessment and Risk Management
Risk assessment and risk management involves the evaluation on how to protect public health. For instance, risk management plans include how much of a substance an industry may release into a lake or river and determine which substances can be stored at a hazardous waste disposal facility; and also control the permissible amount of contamination in drinking water. Regulatory toxicology comprises the investigation of the harmful side view of toxins which differ from other known toxicants. Regulatory toxicology fills in as the imprisonment exposures for individuals and the nature The goal of Regulatory toxicology is to control the production, utility, and testimony of hazardous materials to prevent ecological impact on human wellness and the earth.
Track 13: Computer Aided Drug Designing
Computational methods are important tools to elucidate and guide experiments to hasten the drug design process. Computer-aided drug design (CADD) is of two types of structure-based drug design (SBDD) and ligand-based drug design (LBDD). SBDD is a process of analyzing macromolecular target 3D structural information, proteins or RNA, to identify binding sites and interactions that are required for their assigned biological functions. This information can be utilized for design drugs that can essentially compete with specific interaction consisting of target and thus interrupt the biological pathways required for its survival. LBDD methods concentrate on known ligands for a target sites and set up a relationship with its activity also called as structure-activity relationship (SAR) this information can be used for optimizing known drugs or to design new drugs with increased activity.
Track 14: Post Marketing Surveillance
Post market surveillance is a process in which the medical products are governed to make sure that products are safe, successful and effective. The distribution and supply of medical products is a major step to make sure that the patients are been given the right medical product which is of the best quality, safe and effective. Pharmaceutical companies and distributors, wholesalers and retailers have a responsibility to act in accordance with good manufacturing practice, proper storage, and distribution practices, and this has to be subject for regular inspections by the relevant national regulatory authorities. Regulatory affairs ,or policies methods, and sanctions have been published and applied consistently to those who are knowingly active in the trade of therapeutic products. Distributors and retailers have to clearly show the regulatory authorities from where they purchased or sourced the therapeutic products which they are supplying.
Track 15: Research and Advancements Pharmaceutical Industry
The whole pharmaceutical sector is at a dire need for innovative technological solutions and fundamental scientific work is authorizing the production of thoroughly engineering pharma products. For a commercial-scale of manufacturing of complex drug delivery systems who are using the prevailing technologies as becoming very challenging. Execution of materials science tools has paved a way for molecular-based processing for future in drug delivery system Drugs which are targeting genes for precision medication depend on genetic information for selecting a drug This information is gathered by genome sequencing. Researchers are using this data for finding the specific gene abnormality and later, by understand what drugs the patient gene is responding is found this is called targeted therapy. Recently, 3D printed drug has been approved by the FDA. This technique permits the pill for delivering a high amount of dose of medicine besides being porous enough to dissolve quickly. This is very useful for patients who have a hard time of swallowing their medication This breakthrough clears the way for future 3D printed drugs this area not changes only the method of drugs manufacturing but also administration.
Track 16: New Trends in Pharmaceutical Formulation Development
Nowadays Pharma companies are focusing on developing controlled-release technologies in drug delivery systems which can control the rate of release above the increased period of time. Besides, we would see improved drug dosage formulations, for example, fixed-dose combinations by using variable coated multi plated tablets. Dual release formulations are those consisting of two or more drugs formulated together into a Controlled-release profile which can offer substantial benefits above other dosage forms; such as the reduced risk of dose dumping, sustained concentration in the blood plasma and reduced toxicity, meaning a lower risk of adverse effects. At present inhalation is another crucial center point for formulation development. Specifically, it is been used in the local treatment of respiratory diseases like asthma and chronic obstructive pulmonary disease(OPD). Drugs that are delivered through the lungs give a faster onset of action. The provocation for researchers is developing an effective formulation that can be inhaled safely.
Track 17: Pharmaceutical Engineering
Pharmaceutical Engineering is a part of engineering which concentrates on discovering, formulating, and manufacturing pharmaceutical medicines, along with analytical and quality control processes. It also makes uses of the fields such as chemical engineering, biomedical engineering, and pharmaceutical sciences. Beginning of mass production using a mold named Penicillium chrysogenum which prevented numerous types of bacteria from growing. Scientists identified the prospective of the mold for giving treatment in humans against bacteria that cause bacterial infections. Tissue engineering is a prominent part of the regeneration of functional human tissues. In spite of the body having its intrinsic self-healing properties, the level of repair varies amongst different tissues which may cause major severity during injury or disease.
Track 18: Bioavailability and Bioequivalence in Drug Development
Bioavailability is explained as the extent and rate at which the active pharmaceutical ingredient gets absorbed from the drug product and becomes obtainable at the site of drug action. In vivo bioavailability studies are done on new drugs for setting up an essential pharmacokinetic parameter which includes rate and extent of absorption, rates of excretion and metabolism and elimination half-life when a single and multiple-dose is administrated These important pharmacokinetic parameters are helpful for starting a new dosage regimen. Bioequivalence is used for predicting the in-vivo biological equivalence of two exclusive preparations of drug products. If two drugs are bioequivalent. By determining bioequivalence among two drugs such as a reference drug or branded drug and therapeutic drug which has to be tested against the marketed generic drug. Pharmacokinetic studies are done with which each of the drugs is administered in a cross over study on healthy volunteers. Plasma is collected at regular intervals and assayed. with parent drug or metabolite concentration for estimation of the two drugs.
Track 19: Pharmaceutical Packing and Labeling
Pharmaceutical Packaging is the method of designing, confining or protecting the products during distribution, storage, sale, and use. Pharmaceutical packaging is very organized interdisciplinary with some changes depending on its origin of country and region of storage. Package testing includes the amount of a characteristic property included in the packaging. The properties included are packaging materials, packaging components, primary packages, shipping containers, and unit loads along with the related processes. Testing calculates the effects and interactions of the quality of packaging material, the package content, external forces, and end-use. It involves controlled laboratory experiments, personalized evaluations among people, or field testing. Pharmaceutical Testing is done by qualitative or quantitative methods. Package testing is usually a physical test by using food and pharmaceuticals for packing. And chemical tests are done to determine the sustainability of drug contact materials.
Track 20: Future Advancements in Drug Discovery
Development in Technology as become very crucial in the advancement of drug discovery .One of the example is Phenotypic screening previously it was the basis for discovery of new drugs. The synthesis was screened on cellular or animal disease models to recognize compounds that are the root cause for a prudent change in phenotype. Very recently it has become popular for developing a hypothesis that a definite biological target for a disease is modified , and then screened for substances that regulate the activity of this purified target, then these components are been tested on animals to check if they have the desired therapeutic effect