Fredrik Almqvist, Professor in organic chemistry at Umeå University, and his American research colleague Christina Stallings, receive SEK 24 million from the National Institutes of Health (NIH) for research for combating infections of the most common type of tuberculosis bacteria.
“It’s absolutely amazing! A grant of this size really makes a difference and gives us the endurance that is needed to follow up on our previous research results. An added value is of course that it connects our respective universities in a valuable way, and perhaps opens new paths for other researchers to build similar relationships,” says Fredrik Almqvist, Professor at the Department of chemistry at Umeå University at the Umeå University press release.
New antimycobacterial substances
Within the project, the researchers Fredrik Almqvist and Christina Stallings, Washington University in St. Louis, School of Medicine and visiting researcher at Umeå University for Microbial Research at Umeå University, will develop new antimycobacterial substances that, in combination with existing antibiotics, can be used in the treatment of both drug-sensitive and drug-resistant TB.
“We have developed substances that make the tuberculosis bacteria Mycobacterium tuberculosis sensitive to immune responses and certain antibiotics. Particularly important is that our antimycobacterial substances potentiate the activity of the frontline antibiotic isoniazid and re-sensitize isoniazid resistant TB to isoniazid. We have shown our results in bacterial cultures and will now continue with studies in mice while we develop even more potent tolerance inhibitors, “says Fredrik Almqvist in the press release.
Photo of Fredrik Almqvist: Umeå University