BioArctic has announced that data from the ongoing BAN2401 Phase 2b open-label extension study in early Alzheimer’s disease patients was presented by Eisai at the Clinical Trials in Alzheimer’s Disease (CTAD) conference in San Diego, US.
A subset of patients from the core Phase 2b study enrolled in the open label extension study. The analysis compared baseline assessments from the open-label extension phase with results at the end of the core Phase 2b study. Patients were off treatment between the end of the core Phase 2b study until the start of the Phase 2b extension phase.
The analysis showed that amyloid reductions in the brain that occurred as a result of treatment with BAN2401 persisted after treatment was stopped. Differences in benefits on clinical outcomes were maintained after stopping treatment in patients who received BAN2401 at the two highest doses as compared with patients receiving placebo.
“This baseline open label extension study data is encouraging and supports the consistent benefits seen in the core Phase 2b study. We are pleased with Eisai’s commitment to the program and look forward to the potential for BAN2401 to be a disease modifying treatment for Alzheimer’s disease patients,” said Gunilla Osswald, CEO of BioArctic.
Photo of Gunilla Osswald: BioArctic