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Important clue to tumor regression in neuroblastoma found


The presence of the protein KIF1Bβ can play a central role for the outcome of a neuroblastoma diagnosis. A high percentage of KIF1Bβ means a greater chance of the tumour spontaneously regressing and disappearing.

These are the results of a study by Karolinska Institutet and the Ludwig Institute for Cancer Research. The study is published in the scientific journal Genes and Development.

In the study, the researchers showed that absence of KIF1Bβ contributes to normal neuroblasts not maturing into nerve cells and to a more immature neuroblastoma with a poorer prognosis.

“Our study shows that unimpaired maturing of neuroblasts is a basic prerequisite for spontaneous regression of neuroblastoma. What is behind this regression is unknown, but our study is an important piece in the jigsaw for understanding the mechanisms that cause this phenomenon. Understanding this process in greater detail can provide clues for the development of new therapies. For example, it would be interesting to increase levels of KIF1Bβ activity to see if this facilitates, or even induces, tumour regression,” comments Susanne Schlisio, researcher at KI’s Department of Microbiology, Tumor and Cell Biology and at Ludwig Institute for Cancer Research Ltd.

High gene expression of the NGF receptor TRKA correlates well with good prognoses and with spontaneous regression of the tumour. Conversely, low levels of Trka, partnered with loss of the 1p36 chromosome locus and amplification of the MYCN oncogene, are associated with poor prognoses.

“We have previously shown that the kinesin protein KIF1Bβ, which is present on chromosome 1p36, is a candidate tumour suppressor and that a low expression is correlated with lower survival of neuroblastoma patients,” says Schlisio.

Foto of Susanne Schlisio: Flynn Larsen/LICR

Source: Karolinska Institutet