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Innate immune system worsens the situation in severe COVID-19

In patients with severe COVID-19, the innate immune system overreacts and this overreaction may underlie the formation of blood clots (thrombi) and deterioration in oxygen saturation that affect the patients, show researchers at Uppsala University.

The findings have been published in the journal Frontiers in Immunology.

A waste disposal system

Blood contains numerous proteins that constitute the body’s primary barrier, by both recognizing and destroying microorganisms, including SARS-CoV-2. These proteins are part of the intravascular innate immune system (IIIS), which consists of certain white blood cells, platelets and what are known as the cascade systems of the blood, describes the scientists in a press release. Only 5% of present-day animal species have an immune system that includes T cells and B cells, while the rest rely solely on the natural immune system, which consists largely of the IIIS. With its innate ability to recognize and eliminate foreign substances and particles, such as microorganisms and damaged cells, the IIIS serves as a kind of waste disposal system, they describe.

IIIS is among the drivers of severe COVID-19

In this study, the researchers studied 66 hospital inpatients with severe COVID-19 who were receiving care in the intensive care unit, and found pronounced activation of the IIIS.

“It’s probably the tissue damage, with dead cells in the lungs, that initiates this activation. It can potentially lead to clot formation and poor oxygen saturation due to increased leakage into the blood vessels,” says Bo Nilsson, Professor at the Department of Immunology, Genetics and Pathology, who led the study.

The degree of activation is, in prognostic terms, connected with survival and lung function. Accordingly, the new findings support the notion that the IIIS is among the drivers of severe COVID-19. One explanation why, in some patients with COVID-19, the IIIS acts in this way may be that the cell damage is so extensive that the IIIS overreacts and, rather than helping to clean out the tissue, makes matters worse.

If the IIIS plays the part that the scientists suspect, it might be possible to use drugs that are already approved and used for treating the disease hereditary angioedema for treating severe COVID-19 as well.

Source: Uppsala University

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