Search for content, post, videos

New global study of pharmaceutical contamination in the environment

A new study by an international consortium, including researchers from Stockholm University, looking at the presence of pharmaceuticals in the world’s rivers, found concentrations at potentially toxic levels in more than a quarter of the locations studied.

The new study, published in Proceedings of the National Academy of Sciences, is the first truly global-scale investigation of pharmaceutical contamination in the environment, states the researchers.

“The first truly global-scale investigation of pharmaceutical contamination in the environment.”

“It is well known that pharmaceutical residues end up in lakes and rivers. While the majority of previous studies have monitored active pharmaceutical ingredients in rivers, these studies have often excluded many countries, have measured only a select few pharmaceuticals, and used different analytical methods. This means that it is difficult to make direct comparisons between studies and, hence, assess the scale of pharmaceutical pollution across the globe,” says Anna Sobek, Professor at the Department of Environmental Science and co-author of the study, in an interview with Stella Papadopoulou, Stockholm University.

Read more: Pharma industry confronts growing problem of pharmaceutical waste

Measured the presence of 61 pharmaceuticals

The researchers studied 258 rivers in over half of the world’s countries to measure the presence of 61 pharmaceuticals, such as carbamazepine, metformin and caffeine. Notably, rivers in 36 of these countries having never previously been monitored for pharmaceuticals.

The study included noteworthy rivers such as the Amazon, Mississippi, Thames and the Mekong. More than 1000 water samples were obtained from sites spanning from a Yanomami Village in Venezuela, where modern medicines are not used, to some of the most populated cities on the planet, such as Delhi, London, New York, Lagos and Guangzhou. Areas of political instability such as Baghdad, the Palestinian West Bank and Yaoundé in Cameroon were also included. The climates where samples were obtained varied from high altitude alpine tundra in Colorado and polar regions in Antarctica, to Tunisian deserts.

Truly a global problem

The water sample analysis, which was performed at the University of York’s Centre of Excellence in Mass Spectrometry, UK, found that pharmaceutical pollution is contaminating water on every continent, there are strong correlations between the socioeconomic status of a country and higher pollution of pharmaceuticals in its rivers (with lower-middle income nations the most polluted) and high levels of pharmaceutical pollution was most positively associated with regions of high median age as well as high local unemployment and poverty rates.

“The activities most associated with the highest levels of pharmaceutical pollution included rubbish dumping along river banks, inadequate wastewater infrastructure and pharmaceutical manufacturing, and the dumping of the contents of residual septic tanks into rivers.”

The researchers also found that the most polluted countries and regions of the world are the ones that have been researched the least (namely sub-saharan Africa, South America and parts of southern Asia) and that the activities most associated with the highest levels of pharmaceutical pollution included rubbish dumping along river banks, inadequate wastewater infrastructure and pharmaceutical manufacturing, and the dumping of the contents of residual septic tanks into rivers.

Read more: Nordic solutions for handling pharma waste

They also found that a quarter of the sites contained contaminants (such as sulfamethoxazole, propranolol, ciprofloxacin and loratadine) at potentially harmful concentrations.

“Additionally, in over a fifth of the water samples we analysed, at least one contaminant was measured at concentrations that could negatively impact animals and plants in those rivers.”

”In general, the rivers with the highest level of pharmaceutical pollution were found in low- to medium-income countries where there are no adequate water treatment facilities and where high emissions from the manufacturing of pharmaceuticals are found. Additionally, in over a fifth of the water samples we analysed, at least one contaminant was measured at concentrations that could negatively impact animals and plants in those rivers. Thus, this study shows that pharmaceutical contamination is truly a global problem,” says Sobek.

Read more: Pharmaceuticals are changing fish behavior shows new study

 

Anna Sobek Photo Rickard Kilström

Anna Sobek, Professor at the Department of Environmental Science and co-author of the study. Photo: Rickard Kilström

 

The connection between consumption and waste disposal

The researchers hope that by increasing the monitoring of pharmaceuticals in the environment, they can develop strategies to limit the effects potentially caused by the presence of pollutants.

“I hope the study will lead to projects that support and expand sewage treatment where it is needed the most.”

“This study enables us to understand the connection between consumption and waste disposal. Since we clearly show that access to sewage treatment facilities significantly improves water quality, I hope the study will lead to projects that support and expand sewage treatment where it is needed the most. In addition, the findings of this study remind us that the medicines we buy in pharmacies can have a big impact on the environment of the countries they are manufactured in,” says Sobek.

Source: Stella Papadopoulou/Stockholm University

Featured photo of River Thames: iStock