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Promising data from Alligator Bioscience

Per Norlen Photo Jenny Leyman

Alligator Bioscience has presented the status of its ongoing Phase I clinical trial with the bispecific drug candidate ATOR-1015 developed as tumor-directed therapy for metastatic cancer.

This far, doses of 400 mg (about 6 mg/kg) have been evaluated in the ongoing study and the current dosing is 600 mg (about 10 mg/kg). 18 patients with varying cancer forms (colon cancer, eye melanoma, pancreatic cancer, ovarian cancer, gallbladder cancer, gastric cancer and skin cancer) have been treated and evaluated in terms of safety, and ATOR-1015 has so far been well tolerated.

“We are very proud and happy that our study has been selected for presentation. The promising results so far demonstrate that ATOR-1015 can be administered safely. ATOR-1015 has the potential to be at least as effective as today’s available treatment for these patients, but with significantly fewer side effects,” says Per Norlén, CEO of Alligator Bioscience.

The adverse events in the study were generally mild and transient, all of grade 1 or 2 (on a scale of 1–5). The most common adverse events were infusion-related reactions (five patients). No serious immune-related or dose-limiting adverse events have been reported.

Photo of Per Norlén: Jenny Leyman