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Results from the world’s largest study of cardiovascular disease in type 2 diabetes

Cities changing diabetes Novo Nordisk

Novo Nordisk has announced the results of the CAPTURE study, a global non-interventional study to uncover the prevalence of cardiovascular disease and risk and its management in people living with type 2 diabetes.

The study, the first of its kind and involving nearly 10,000 participants from 13 countries across five continents, showed that 1 in 3 people with type 2 diabetes have established cardiovascular disease, and 9 in 10 of these had atherosclerotic cardiovascular disease. Atherosclerotic cardiovascular disease is caused by the build-up of fats, cholesterol and other substances in and on the artery walls, which narrows the vessels and results in reduced blood flow, potentially leading to events like heart attack and stroke. CAPTURE also highlighted that only 2 in 10 people with type 2 diabetes and atherosclerotic cardiovascular disease are receiving a glucose-lowering treatment with proven cardiovascular benefits.

“The data highlight that while the prevalence of atherosclerotic cardiovascular disease within the type 2 diabetes population is high, the vast majority are not being managed with treatments that are proven to reduce the risk of potentially life-altering cardiovascular events,” says study investigator Dr Ofri Mosenzon, who consults for Novo Nordisk and the Diabetes Unit at the Hadassah Medical Center in Israel. “It is critical that we prioritize cardiovascular disease as a key factor in the management of type 2 diabetes. People with type 2 diabetes need to be more aware of their risk factors and physicians need to be actively screening for them. Today, we can address this risk through treatments with proven cardiovascular benefits, as recommended by various treatment guidelines.”

Information from both primary and secondary care settings

For the first time, information on cardiovascular disease in type 2 diabetes has been gathered from both primary and secondary care settings, also reflecting that a significant proportion of people with type 2 diabetes are being treated by primary care physicians in conjunction with diabetes specialists.

“Cardiovascular disease is the leading cause of disability and death among people with type 2 diabetes. Until recently, the importance of this link between type 2 diabetes and cardiovascular disease was not fully recognized on a global scale,” says Stephen Gough, chief medical officer at Novo Nordisk. “Through our ongoing investment, including the CAPTURE study, Novo Nordisk hopes that with increased understanding of the disease and its management, healthcare professionals will have greater knowledge of the most appropriate way to manage this disease and improve patient outcomes.”

Photo: Cities Changing Diabetes launch in Copenhagen 2014. Blågårdsgade, Copenhagen, Denmark