NLS

As weather warms, heart attack risks may decline, says a Lund University study. Heart attacks seem more common in winter, doctors have long observed, including in a nearly 100-year-old clinical paper. To see if a rigorous analysis supports this observation, Lund University researchers merged data from SWEDEHEART, the registry for acute cardiac care outcomes in […]

The TEDDY study – which includes kids in Finland and Sweden – is finding factors that influence type 1 diabetes. Type 1 diabetes (T1D), which is often diagnosed in childhood, results from a complex interaction of genetic and environmental factors, including the gut microbiome. To identify influencers of T1D development, the Environmental Determinants of Diabetes […]

New studies focus on B cells in lymphoid structures within tumors. Three recent papers in Nature could help improve cancer treatment by immune checkpoint blockade (ICB). Checkpoint inhibitors such as the antibody therapies ipilimumab, nivolumab, and pembrolizumab promote a response against cancer by blocking CTLA-4, PD-1, or PD-L1. The research behind this therapy was recognized […]

New results could help select patients who might benefit most from BAFF inhibitors for autoimmune diseases. Many autoimmune conditions such as multiple sclerosis and rheumatoid arthritis are more common in women than men. A clue about this disparity is that high levels of the male sex hormone testosterone and its receptor correlate with low numbers […]

Read Chris Tachibana's exclusive interview with Frances H. Arnold, a Nobel Laureate in Chemistry 2018, and learn more about her bold approaches to optimizing enzymes for society’s benefit.

Phage display is used to discover antibody therapies including Humira for rheumatoid arthritis, Portrazza for cancer, and Benlysta for lupus.