Diaprost has announced a publication in the journal of Clinical Cancer Research on PSA-targeted Alpha-, Beta- and Positron Emitting Immuno-Theranostics in Murine Prostate Cancer Models and Non-Human Primates.
The extensive preclinical study was conducted at Memorial Sloan Kettering Cancer Center (MSK) on Diaprost’s propriety antibody (hu5A10) targeting PSA. This preclinical evaluation of radiolabeled hu5A10-based compounds in prostate cancer (PCa) mouse models and non-human primates, establishes hu5A10 as a promising theranostic (therapy and diagnostic) agent that allows specific and effective delivery of radionuclides to androgen receptor driven prostate tissue. The reported data strongly supports Diaprost’s planned efforts to translate h5A10 to patients.
Diaprost, a private pharmaceutical research and development company based in Lund, Sweden whose principal asset is hu5A10 targeting PSA, previously announced an exclusive license agreement with MSK for intellectual property (IP) related to the use of PSA antibodies for therapeutic and diagnostic purposes for prostate cancer.
“These results clearly show that PSA-targeted alpha-particle therapy is a very promising option for patients with generalized and castration resistant PCa,” says Johan Drott, the CEO of Diaprost. “There is an urgent need for therapeutic compounds that result in substantial treatment effects and long-term survival in patients with metastatic PCa. Based on this promising data, we think that hu5A10 is a unique candidate, and we are looking forward to clinical development to be initiated.”
This hu5A10 project follows in the footsteps of Diaprost’s earlier work in prostate cancer focusing on the hK2 antibody (hu11B6) which led to a sale of the asset to a leading global pharmaceutical company.
Photo of Johan Drott, CEO, Diaprost