The study results mark an important milestone in the development of OX390, an emergency treatment to reverse overdoses involving xylazine and medetomidine, alpha-2 agonists often referred to as “Tranq” and “Rhino Tranq”, respectively.

The study demonstrated rapid and substantial intranasal absorption of atipamezole, successfully establishing proof-of-concept across multiple formulations. The results support that a single nasal dose of OX390 achieves exposure within the targeted therapeutic range. The next milestone in the project is an upcoming type C meeting with the FDA to agree on the non-clinical development plan that will enable human clinical trials.

“I am very pleased with the in-vivo results, it clearly supports the continued development of OX390 and is another proof-of-concept not only for OX390, but also for Orexo’s proprietary AmorphOX technology. Once again nasal delivery using the AmorphOX technology is confirmed to provide rapid absorption and high bioavailability,” says Nikolaj Sorensen, CEO & President of Orexo.