“Drug discovery increasingly requires seamless integration between chemistry and biology,” says Michael Dabrowski, Chief Executive Officer of Pelago Bioscience. “By bringing RG Discovery into Pelago Bioscience, we can offer customers a single scientific partner capable of designing and synthesizing compounds, evaluating target engagement in living cells, and rapidly feeding those insights back into the next design cycle. This combination strengthens our ability to help customers progress programs faster and with greater confidence.”

Closes the loop between compound design, synthesis, and market leading, direct in-cell target engagement

Pelago Bioscience’s Cellular Thermal Shift Assay (CETSA)-based platform provides direct insight into how compounds engage their targets in living cells – data that now can feed straight back into RG Discovery’s next round of compound design, a continuous chemistry-to-biology cycle that neither a chemistry nor pure-biology CRO can offer, states Pelago. Hence, the combination closes the loop between compound design, synthesis, and market leading, direct in-cell target engagement – removing the vendor handoffs that slow programs from hit to lead, the company states.

RG Discovery

Founded in 2011 by former AstraZeneca scientists, RG Discovery has built a reputation for solving complex chemistry challenges for biotechnology and pharmaceutical companies. The company employs approximately 40 scientists and operates from Medicon Village in Lund, Sweden, where its facilities include chemistry and analytical infrastructure supporting a broad range of drug discovery activities.

“RG Discovery has always focused on helping customers solve difficult scientific problems through close collaboration and deep technical expertise,” says Johan Evenäs, CEO and co-founder of RG Discovery. “Joining forces with Pelago Bioscience allows us to expand that impact by combining world-class chemistry with world-class target engagement science. We are excited about the opportunities this creates for both our customers and our team.”