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Targovax starts expansion part in the phase I/II trial with ONCOS-102 in combination with durvalumab

Research clinical trials

All safety reviews during the dose escalation phase have been completed with no Dose Limiting Toxicities (DLT) reported and the five US hospital sites are now open for further recruitment.

This phase I/II trial investigates the safety, biologic and anti-tumor activity of ONCOS-102 in combination with Imfinzi (durvalumab, anti-PD-L1) in patients with advanced peritoneal malignancies who have failed prior standard chemotherapy and have histologically confirmed platinum-resistant or refractory epithelial ovarian or colorectal cancer.

The sponsor of the trial is Ludwig Institute for Cancer Research with coordination and funding support from the Cancer Research Institute.