Search for content, post, videos

Nuevolution in scientific article with Nobel Laureate


Nuevolution announces the publication of the scientific article entitled “An allosteric “Beta-Blocker” isolated from a DNA-encoded small molecule library” in the Proceedings of the National Academy of Sciences, USA.

The article presents work from the ongoing collaboration between Nuevolution and the group of Nobel Laureate Dr. Robert J. Lefkowitz at Duke University involving the screening of Nuevolution compound libraries against an important class of targets named GPCRs involved in signaling across cell-membranes. The results of the collaboration provide Nuevolution with attractive methods for the screening of challenging membrane bound targets.

“The collaboration with Dr Lefkowitz’ group is focused on answering some of the fundamental details of signalling through GPCR receptors, and we are very excited to see some of the joint work now being published” said Thomas Franch, CSO of Nuevolution and continued “We look forward to continuing the productive research collaboration with the Lefkowitz group to further expand the applicability of our technology to difficult membrane bound targets, and to seek answers and understand the details of GPCR receptor signalling mechanisms”.