NLS research-box

Swedish researchers and doctors have successfully treated a child with neuroblastoma by using a tailored precision medicine approach. “Combining genetic mapping and biological understanding with a new targeted treatment is precision medicine made real, which can make a difference and cure more children who have cancer,” says co-last author Per Kogner (Karolinska Institutet/Astrid Lindgren Children’s […]

Scientists at deCODE genetics have demonstrated how measuring the levels of a large number of proteins in plasma at a population scale when combined with data on sequence diversity and RNA expression dramatically increases insights into human diseases and other phenotypes. The scientists have used levels of five thousand proteins in plasma targeted on a […]

An international research team have mapped how the signalling molecules caused by exercise are releases by different organs in mice following exercise at different times of the day. Their atlas of exercise metabolism, published in the journal Cell Metabolism, may in the long term contribute to more effective exercise therapies that are timed to the […]

A new invention to measure the size of protein aggregates (proteins that clump together) can determine very precisely whether a person has systemic lupus erythematosus (SLE) or not and the severity if they have it. The research has been published in the Proceedings of the National Academy of Sciences of the United States of America. “Our […]

Researchers from Karolinska Institutet and the SciLifeLab Chemical Biology Consortium Sweden (CBCS) have identified a chemical compound, CBK77, that has the potential to inhibit protein recycling in cancer cells, subsequently leading to tumor cell death. CBK77 also turned out to have an unexpected advantage, it only affects cells that express the NQO1 enzyme, commonly upregulated […]

Researchers at Karolinska Institutet, Umeå University, and the University of Bonn have identified a new group of molecules that have an antibacterial effect against many antibiotic-resistant bacteria. Since the properties of the molecules can easily be altered chemically, the hope is to develop new, effective antibiotics with few side effects. The findings have been published […]